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David C. Glahn

University of Texas Health Science Center at San Antonio

glahn@uthscsa.edu

Mail Code 7792, 7703 Floyd Curl Drive

San Antonio, Texas 78229-3900
United States
210-567-5508

David Glahn's Website
UTHSCSA Psychiatry
CV
NIH Biosketch
NSF Biosketch

Keywords:
psychosis, schizophrenia, bipolar disorder, genetics, MRI, neuropsychology

Statement:
Dr. David Glahn joined the Department of Psychiatry (UTHSCSA) and the Research Imaging Center (RIC) in July of 2002. He received his doctorate in psychology from the University of Pennsylvania in 2000 and completed a post-doctoral fellowship at the University of California at Los Angeles. Glahnís research focuses on applying neurocognitive and neuroimaging measures in genetic studies of schizophrenia and bipolar disorder. Localization of genes involved in schizophrenia and/or bipolar disorder should significantly contribute to an understanding of the underlying biology of these complex diseases, which in turn should improve future treatments and create the potential for prevention strategies. After joining UTHSCSA, Glahn developed a computerized system to facilitate the administration and data management of neurocognitive tests for use in genetic linkage studies. In collaboration with faculty in the Department of Psychiatry, Glahn has applied this neuropsychological test battery in over 35 studies, collecting over 700 assessments in various populations. Currently, the battery is being administered in an NIMH funded linkage study of schizophrenia (total sample >1500) and will soon be applied in a comparable study of bipolar disorder (n~3,400). The bipolar study includes structural neuroimaging endophenotypes, allowing for multimodal assessments of central nervous system integrity of those affected by bipolar disorder and their relatives. Glahn was recently named chief of the neuroimaging core in the Department of Psychiatry. In this role, he consults with faculty in Psychiatry and elsewhere in the development, analysis and interpretation of neuroimaging experiments. Glahnís own neuroimaging research focus on elucidating the neurophysiologic underpinning of cognitive processes found to be sensitive to genetic liability for schizophrenia or bipolar disorder. In addition to studying psychiatric illnesses, Glahnís work includes the clarifying genetic influences on normal brain function and structure. As the markers developed in his laboratory are sensitive to variation within the normal population, these measures provide a potential window for determining the genetic contributions to neurocognitive processing and brain structure and function in healthy individuals.

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