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Michael WL. Chee

Duke-NUS Graduate Medical School

7th Hospital Drive
Singapore, 169611

Michael Chee's Website
Duke-NUS Graduate Medical School
Brain Imaging and Analysis Centre - Duke University
NIH Biosketch
NSF Biosketch

fMRI, sleep deprivation, aging, brain imaging, cognitive neuroscience

My research is in the realm of cognitive neuroscience and spans two areas: cognition in the context of sleep deprivation and healthy cognitive aging. The common thread linking these seemingly unrelated themes is the goal of furthering human cognitive performance through discovering and validating imaging markers that help differentiate individuals according to their inherent cognitive abilities. The methods developed in the course of my research are intended to evaluate the effect of interventions that could improve cognitive performance. The knowledge generated by my work will be applied to the evaluation of behavioral and pharmacologic interventions intended to enhance human cognition. Sleep Deprivation I have been studying the effect of short-term total sleep deprivation (TSD) on healthy young adults from 20 . 40 years of age to: a.Characterize its effects on working memory and sustained attention and their neural correlates using a combination of behavioral tests, EEG and functional magnetic resonance imaging (fMRI). b.Determine the range of inter-individual variation of performance in working memory and sustained attention under conditions of TSD with a view to identify imaging and neurophysiological markers for vulnerability of sleep deprivation. Healthy Brain Aging The goal of studying the healthy aging brain is to characterize the extent to which modifiable risk factors result in either positive or deleterious effects on brain morphology and function. Preliminary data suggests that healthy, cognitively intact elders show slower rates of brain atrophy than their less healthy peers. By evaluating positive and negative correlates of accelerated atrophy or change in functional activation, specific interventions that might be used to prevent cognitive loss in our population can thus be evaluated. The promise of using MR imaging as a biomarker to test the efficacy of preventive measures is strengthened by empirical evidence showing that relative to neuropsychological tests, the use of MR reduces the number of persons that need to be recruited in order to show a similar treatment effect, by an order of magnitude.

I sincerely apologize that we have a long-standing and unresolved problem that users are unable to modify the database contents using their logins and passwords. I hope that we can fix this problem soon. In the meantime, I will try to do this manually as best I can.

-- Mark Cohen

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