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Alexander J. Shackman

Wisconsin Psychiatric Institute & Clinics
6001 Research Park Boulevard
Madison, Wisconsin 53719
United States

Alexander Shackman's Website
NIH Biosketch
NSF Biosketch


I am interested in how cognitive and emotional processes interact. Studying such interactions is a promising means of answering more general questions about how the brain in general and the prefrontal cortex in particular are functionally organized and how it contributes to adaptive and maladaptive behavior. My research falls into three more specific lines of work. One line aims to understand the psychological and neural mechanisms that mediate anxiety's impact on how we think and act. Here, we have examined the effects of experimentally induced anxiety on cognitive tasks thought to rely on prefrontal cortex. We have also sought to better characterize how individual differences in anxious temperament, emotion regulation, and working memory capacity can minimize or intensify threat's impact. A second line aims to identify the functional significance of aberrant activity in the prefrontal cortex of individuals afflicted with major depression. In particular, we are trying to tease apart the contributions of exaggerated emotional reactivity from deficient emotion regulation. A third line of work uses transcranial magnetic stimulation (TMS) to directly manipulate prefrontal activity, indexed by simultaneously recorded electrophysiological (EEG) and hemodynamic (fMRI) measures. Common to each of these areas is a strong interest in quantitative and physiological methodology.

I sincerely apologize that we have a long-standing and unresolved problem that users are unable to modify the database contents using their logins and passwords. I hope that we can fix this problem soon. In the meantime, I will try to do this manually as best I can.

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