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Irma Rukhadze

11301 Wilshire Blvd. Bldg.114, room 305

Los Angeles, California 90073
United States
310-478-3711 ext: 41925

Irma Rukhadze's Website
NIH Biosketch
NSF Biosketch

Sleep related breating disorders, Obstructive Sleep Apnea, Upper Airway Muscles

My research primarily focused on sleep-related breathing disorders, specifically, on the neural mechanisms of Obstructive Sleep Apnea (OSA) pathogenesis. I am investigating the noradrenergic neurotransmission in the state-dependent activity of upper airway muscles as one of the key factor of upper airway collapse during sleep. To address this question, I am performing the basic research using the transgenic animal models and viral-vector (Designer Receptors Exclusively Activated by the Designer Drug (DREADDs) and conditional tracers) technologies to delineate the key neural mechanisms responsible for sleep-related state-dependent activity of upper airway muscles in freely behaving mice. I am also interested in translational research. My clinical research interests rest in OSA in young and elderly population and neurodegenerative diseases.

I sincerely apologize that we have a long-standing and unresolved problem that users are unable to modify the database contents using their logins and passwords. I hope that we can fix this problem soon. In the meantime, I will try to do this manually as best I can.

-- Mark Cohen

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