MR Imaging & Applications

Manganese Toxicity

Elemental manganese is present in significant amounts in the environment and is highy neurotoxic, but its hazards are under-recognized (in many cases it carries minimal toxic labeling: e.g., Sigma-Aldrich). It is used also as an MRI contrast agent routinely exposing researchers during use. Our lab has been exploring the mechanisms of toxicity and the pharmacokinetics of manganese.

Pallidum tracts

Diffusion Tensor Image (DTI) based tract rendering of fibers crossing through the
Pallidum as defined by the Harvard-Oxford Subcortical Atlas. From PK Douglas Doctoral Dissertation, 2010

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